The COVID-19 pandemic endangers the health of all, with the most vulnerable communities often being the last in line for support. Among these are adolescents and young people living with HIV and young key affected populations, including young people who use drugs, young people from the LGBTIQ+ community and young sex workers. Read the article written by Julian Kerboghossian, Cedric Nininahazwe, Tinashe Rufurwadzo, Gaj Bahadur Gurung, Ailish Brennan, and Mohammed Amine Gahfez in English and French.